- Sam Sheppard, who inspired the TV series and movieThe Fugitive
- Jeffrey McDonald, who became the subject of the bestsellerFatal Vision
- Mister Perfect, Brad Cunningham, who was convicted of bludgeoning his wife to death
- Michael Peterson, who was the subject of the IFC documentary series The Staircase and a Lifetime movie original starring Treat Williams
- OJ Simpson, whose dream team of lawyers defended the former pro-football player and movie star of the brutal murder of his ex-wife as the entire nation watched
- Claus von Bulow, immortalized in the book and movieReversal of Fortune
- Robert Blake, former TV star, who was suspected of engineering the death of his conwoman wife
- Scott Peterson, a philandering sociopathic husband who almost escaped arrest for the murder of his wife and unborn child.
- Lambert "Bart" Knol, who claimed he suffered from "substance-induced persistent amnesia" when he was accused of killing his wife of 38 years
These cases and others are presented in an objective manner by a knowledgeable voice that recognizes that suspicion, and sometimes even conviction, are not always synonymous with guilt.